Ji-Yeon Yu 1 , Jae Yeo Ha 1 , Kyung-Mi Kim 2 , Young-Suk Jung 3 , Jae-Chul Jung 2,
*
and Seikwan Oh
Molecules 2015, 20, 13041-13054;
Published: 20 July 2015
The Ruboril series, with patented β-Calm Complex technology, is specifically designed to soothe and protect skin prone to redness. This technology has a triple-action mechanism: targeting redness caused by dilated superficial blood vessels, calming skin inflammation, and strengthening sensitive skin’s natural defenses.
With an optimal concentration of carefully selected active ingredients, Ruboril works directly at the root source of redness, helping reduce persistent erythema in rosacea and redness in sensitive skin. In just a few days, skin feels more comfortable, calm, and healthy.
Ruboril guarantees excellent tolerance even for the most reactive skin, making it the perfect solution for patients with rosacea and sensitive skin that is prone to redness.
Used as an intensive spot treatment.
Ruboril works through the β-Calm Complex, a combination of active ingredients that synergistically targets three key mechanisms in rosacea:
1. Vascular effects – helps reduce superficial blood vessel dilation, thereby reducing persistent redness –> Yeast and plant extracts such as Centella Asiatica, Calendula Officinalis, Horseradish Cestnut, Butcher’s Broom, and Licorice extract
2. Anti-inflammatory effects – soothes the skin by inhibiting inflammatory mediators that trigger flare-ups, burning, and stinging –> β-glycyrrhetinic acid
3. Skin barrier repair – increases hydration and strengthens the skin’s protective barrier, making the skin more resistant to rosacea triggers –> Niacinamide and Betaine
Ruboril is unique because it works directly on two of the main causes of redness in rosacea:
1. Targeting superficial blood vessel dilation (vascularization), which helps vasoconstrict.
2. Simultaneously reducing inflammation, thereby helping reduce persistent redness and skin flare-ups.
It also helps repair the skin barrier, resulting in much healthier skin.
Using Uveblock Mineral Invisible or Tinted can provide more protection from sunlight without any ingredients being absorbed by the skin.
Clinically proven starting from 1 month (28 days) of use:
Ruboril Expert Intense*
1. Reduces erythema 4x higher than placebo
2. 143% effective in reducing the number of telangiectasias
Ruboril Expert M** & Expert S***
1. 70% effective in reducing erythema
2. 14% effective in reducing the number of telangiectasias
3. 80% effective in increasing hydration (Ruboril Expert S)
*Self-assessment on 20 volunteers, for 28 days, 2 applications per day. Dermatologically tested.
**Self-assessment on 20 volunteers, for 28 days, 2 applications per day. Dermatologically tested.
***Assessment using a corneometer on 11 volunteers with dry skin, 1 application per day
Ji-Yeon Yu 1 , Jae Yeo Ha 1 , Kyung-Mi Kim 2 , Young-Suk Jung 3 , Jae-Chul Jung 2,
*
and Seikwan Oh
Molecules 2015, 20, 13041-13054;
Published: 20 July 2015
hanane Chajra1
Mahdi nadim2
Daniel auriol3
Kuno schweikert1
Fabrice lefevre1
1Induchem ag, Volkestwil, switzerland;
2CBM-Cnrs, Orléans Cedex,
3libragen sa, Toulouse, France
Clinical, Cosmetic and Investigational Dermatology
Multifunctional molecules for erythematotelangiectatic rosacea disorder
Maria Manuel Baía de Melo Magalhães Gonçalves1,
Maria Eugénia Soares Rodrigues Tavares de Pina1,2*
1 Faculty of Pharmacy, University of Coimbra, 2 CIEPQPF, Research Center for Chemical Processes Engineering and Forest
Products, Chemical Engineering Department, Faculty of Sciences and Technology, University of Coimbra, Portugal
Brazilian Journal of Pharmaceutical Sciences 2017
A. Kowalska and U. Kalinowska-Lis
Department of Cosmetic Raw Materials Chemistry, Medical University of Lodz, Muszynskiego 1,90-151,Lodz, Poland
International Journal of Cosmetic Science, 2019
Julia Hoffmann, Fabian Gendrisch, Christoph Mathis Schempp and Ute Wölfle *
Biomedicines
Published: 8 February 2020
lulia Semenescu 1,2, Diana Similie 1,2,*, Zorita Diaconeasa 3 and Corina Danciu
Pharmaceuticals 2024
Published: 6 February 2024
Rui Yang, Bo-Chuan Yuan, Yong-Sheng Ma, Shan Zhou and Ying Liu
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China
PHARMACEUTICAL BIOLOGY, 2017
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ISISPHARMA laboratories were founded in 1987 by a visionary chemist driven by the desire to put the group’s expertise at the service of healthcare professionals and patients. Collaboration with scientific communities and universities means the products benefit from the latest scientific research into skin homeostasis.
Homeostasis, like any form of equilibrium, is fragile and can be altered when aggressions become too strong.Extreme temperatures, sun exposure, detergents, dryness, irritation, inflammation, bacteria and hormonal disorders are all factors that can visibly disrupt skin balance. The solutions developed by ISISPHARMA do not alter the skin’s nature and allow it recover its natural balance. ISISPHARMA helps the skin in all its essential functions by correcting and preventing disorders.