January 26, 2017 by Dermatology News
SENTE, with its patented Heparan Sulfate Analog (HSA) technology, is a breakthrough in aesthetic dermatology, focusing on the utilization of glycosaminoglycans (GAGs), a key component in maintaining skin balance. HSA works by maintaining intercellular communication, strengthening the skin barrier, and regulating the inflammatory response.
All of these benefits have been proven through clinical trials, making SENTE not just a skincare product, but a scientific solution that supports skin regeneration, maintains moisture, and increases skin’s tolerance to external factors.
SENTE is highly recommended for use after aesthetic procedures because it functions as a repair booster that re-stimulates the body’s natural growth factors, thereby accelerating the recovery process and strengthening treatment results.
With its HSA-based formulation, SENTE helps patients achieve healthier, stronger, and more protected skin, even in vulnerable and sensitive skin conditions.
1. SENTE Dermal Repair Cream
When to use: Morning and evening.
How to use: Apply a thin layer evenly to the face and neck after cleansing.
Note: Can be used immediately after aesthetic procedures to repair skin and aid wound healing, and also as a daily moisturizer, including for sensitive or reddened skin.
2. SENTE Cysteamine HSA Cream
When to use: Evening.
How to use:
1. Cleanse skin.
2. Apply a thin layer to hyperpigmented areas (e.g., melasma or dark spots).
3. Leave on for approximately 15 minutes, then rinse with a gentle cleanser.
4. Afterward, apply moisturizer.
Note: Start with a frequency of 2–3 times a week, then increase as skin tolerates. Use sunscreen in the morning/afternoon.
3. SENTE Even Tone Retinol
When to use: Evening.
How to use:
1. Apply to cleansed, dry skin.
2. Apply a thin layer to the entire face, avoiding the eye area.
3. Start with 2–3 times a week, then increase to every night as tolerated.
Note: Always apply sunscreen in the morning as retinol increases skin sensitivity to UV rays.
1. Replaces and mimics the natural function of Heparan Sulfate (HS).
HS is a component of glycosaminoglycans (GAGs), which are essential for maintaining skin balance.
With aging or damaged skin, natural HS levels decrease, disrupting intercellular communication and slowing skin repair.
HSA (Heparan Sulfate Analog) in SENTE is designed to mimic natural HS and restore its function.
2. Strengthens intercellular communication
HS acts as a “master organizer” in the extracellular matrix (ECM).
With HSA, communication between fibroblasts, keratinocytes, and growth factors remains optimal, making the skin more responsive to self-repair.
3. Regulates the inflammatory response
HSA can reduce the activity of pro-inflammatory mediators that trigger redness, irritation, and hyperpigmentation.
Helps soothe sensitive skin or those after aesthetic procedures.
4. Supports skin repair and regeneration
HSA binds growth factors (such as FGF, VEGF, TGF-β) to maintain stability and work more effectively in the skin.
Effect: Increases natural collagen, elastin, and hyaluronic acid, resulting in firmer, more elastic, and healthier skin.
5. Strengthens the skin barrier
By stimulating the formation of structural components in the skin, HSA maintains the integrity of the skin barrier, making it more resistant to environmental irritation and aging.
SENTE presents patented Heparan Sulfate Analog (HSA) technology, the only skincare product capable of mimicking the natural function of glycosaminoglycans. HSA acts as the skin’s “master regulator”: strengthening the skin barrier, optimizing natural growth factors, calming inflammation, and supporting post-aesthetic recovery with high tolerance, even for sensitive skin.
SENTE can be a core product (core treatment), but still needs basic complements (cleanser + sunscreen)
Published online May 31, 2023
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We are not an overnight success. We are medical grade skincare pioneers who discovered how to replenish our skin's diminishing supply of Heparan Sulfate, a natural component of our skin that it needs to regulate inflammation, control visible redness, restore even skin tone, and stay hydrated, plump and firm.
Our clinically-derived Heparan Sulfate Analog (HSA) has been used by medical professionals for decades to aid in the body's healing process of inflammation. Senté was the first and only company in the world to successfully modify a form of HSA that can be infused into topical products to help repair damaged skin.
Since 2007, we have helped physicians address the uneven skin concerns of their patients. Now Senté is available directly to you.
Senté exists to put its technology and professionally vetted formulas to work for all skin tones and types. To cut through the hype with purposeful products. To give you exactly what your skin needs, creating a true path to your best skin.
